Scientist - Gene Delivery and Editing Process Development

Company: Disability Solutions
Location: Seattle
Posted on: November 6, 2024

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: .Title: Scientist - Gene Delivery and Editing Process DevelopmentLocation: Seattle, WAWe are looking for a successful scientist who will directly employ techniques for the in vitro production of oligonucleotides , and biophysical and analytical tools to develop our next-generation gene edited therapies . An outstanding candidate will be driven by a desire to create, optimize, and define novel processes that are not currently utilized by BMS. Key Responsibilities:

• E xecute nucleic acid ligation reactions using splint ligation methodology
  • E xecute in vitro transcription reactions to produce RNA
    • Execute downstream purification of crude RNA products using anion exchange chromatography, reverse-phase (RP) chromatography, and buffe r exchange unit operations
      • E xecute ion-pairing RP chromatography assays to measure RNA full-length product purity
        • Execute native and denaturing PAGE (or capillary electrophoresis , CE ) assays
          • Execute Cas nuclease binding assays (fluorescence based) for various gRNA constructs
            • Actively participate and support lab maintenance and continuous improvement initiatives
              • Maintain accurate and detailed laboratory notebook s and documentation
                • Summarize and present data in group meetings and contribute to group discussions
                  • Author technical memos and reports Qualifications & Experience:
                    • STEM degree with 2+ years of relevant industry experience
                      • Experience working with, storing, and analyzing purified nucleic acids and proteins
                        • Independently motivated , and possesses the ability to work creatively with limited resources
                          • Ability to communicate clearly and concisely through oral presentation and technical writing
                            • Ability to leverage literature, and internal and external resources to form hypotheses
                              • Degree in chemistry, biochemistry, molecular biology, or bio-related field, preferred
                                • Experience with optimizing molecular cloning reactions, preferred
                                  • Familiarity with bioinformatic tools used to predict RNA secondary structure, preferred
                                    • Experience with JMP for DoE design and analysis, preferred If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. The starting compensation for this job is a range from $97,000 - $121,000, plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site. Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program. #LI-OnsiteBMSCARTVETERANIf you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as Transforming patients' lives through science--- , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

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